Semin Liver Dis 2015; 35(04): 355-360
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. Genome-Wide Association Studies and Liver Disease
Elizabeth K. Speliotes
1
Divisions of Gastroenterology, and Computational Medicine and Bioinformatics, Department
of Internal Medicine, University of Michigan, Ann Arbor, Michigan
› Author Affiliations
References
1 Cargill M, Altshuler D, Ireland J , et al. Characterization of single-nucleotide
polymorphisms in coding regions of human genes. Nat Genet 1999; 22 (3) 231-238 2 Halushka MK, Fan JB, Bentley K , et al. Patterns of single-nucleotide polymorphisms
in candidate genes for blood-pressure homeostasis. Nat Genet 1999; 22 (3) 239-247
3 Li WH, Sadler LA. Low nucleotide diversity in man. Genetics 1991; 129 (2) 513-523
4 Wang DG, Fan JB, Siao CJ , et al. Large-scale identification, mapping, and genotyping
of single-nucleotide polymorphisms in the human genome. Science 1998; 280 (5366) 1077-1082
5 Kruglyak L, Nickerson DA. Variation is the spice of life. Nat Genet 2001; 27 (3)
234-236 6 Reich DE, Gabriel SB, Altshuler D. Quality and completeness of SNP databases. Nat
Genet 2003; 33 (4) 457-458 7 Gibbs RA, Belmont JW, Hardenbol P , et al; International HapMap Consortium. The
International HapMap Project. Nature 2003; 426 (6968) 789-796 8 International HapMap Consortium. A haplotype map of the human genome. Nature 2005;
437 (7063) 1299-1320 9 Welter D, MacArthur J, Morales J , et al. The NHGRI GWAS Catalog, a curated resource
of SNP-trait associations. Nucleic Acids Res 2014; 42 (Database issue): D1001-D1006
10 McCarthy MI, Abecasis GR, Cardon LR , et al. Genome-wide association studies for
complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008; 9 (5) 356-369
11 Chanock SJ, Manolio T, Boehnke M , et al; NCI-NHGRI Working Group on Replication
in Association Studies. Replicating genotype-phenotype associations. Nature 2007;
447 (7145) 655-660 12 Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components
analysis corrects for stratification in genome-wide association studies. Nat Genet
2006; 38 (8) 904-909 13 Rice TK, Schork NJ, Rao DC. Methods for handling multiple testing. Adv Genet 2008;
60: 293-308 14 Pe'er I, Yelensky R, Altshuler D, Daly MJ. Estimation of the multiple testing burden
for genomewide association studies of nearly all common variants. Genet Epidemiol
2008; 32 (4) 381-385 15 Park J-H, Wacholder S, Gail MH , et al. Estimation of effect size distribution from
genome-wide association studies and implications for future discoveries. Nat Genet
2010; 42 (7) 570-575 16 Speliotes EK, Willer CJ, Berndt SI , et al; MAGIC; Procardis Consortium. Association
analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nat Genet 2010; 42 (11) 937-948 17 Darabi H, Humphreys K. Single- and multi-locus association tests incorporating phenotype
heterogeneity. Hum Hered 2011; 71 (1) 11-22 18 Anderson CA, Pettersson FH, Barrett JC , et al. Evaluating the effects of imputation
on the power, coverage, and cost efficiency of genome-wide SNP platforms. Am J Hum
Genet 2008; 83 (1) 112-119 19 Pe'er I, de Bakker PI, Maller J, Yelensky R, Altshuler D, Daly MJ. Evaluating and
improving power in whole-genome association studies using fixed marker sets. Nat Genet
2006; 38 (6) 663-667 20 Manning AK, LaValley M, Liu CT , et al. Meta-analysis of gene-environment interaction:
joint estimation of SNP and SNP × environment regression coefficients. Genet Epidemiol
2011; 35 (1) 11-18 21 Zhang X, Huang S, Zou F, Wang W. Tools for efficient epistasis detection in genome-wide
association study. Source Code Biol Med 2011; 6 (1) 1 22 Willer CJ, Speliotes EK, Loos RJ , et al; Wellcome Trust Case Control Consortium;
Genetic Investigation of ANthropometric Traits Consortium. Six new loci associated
with body mass index highlight a neuronal influence on body weight regulation. Nat
Genet 2009; 41 (1) 25-34 23 Lango Allen H, Estrada K, Lettre G , et al. Hundreds of variants clustered in genomic
loci and biological pathways affect human height. Nature 2010; 467 (7317) 832-838
